COMPLETED

• Osteocyte/chondrocyte stem cell isolation and growth using tricalcium phosphate cubes as culture media

• Ankle positioning and its effect on lateral calcaneal flap perfusion using laser doppler flowmetry

• Soft tissue edema associated with rhBMP-2 implantation in an ectopic rat model

• Numerous clinical and radiologic outcome studies after multilevel and hybrid artificial disc replacements in both cervical and lumbar spine

ONGOING

• POST APPROVAL STUDY PROTOCOL for the SIMPLIFY® CERVICAL ARTIFICIAL DISC

• POST APPROVAL STUDY PROTOCOL FOR THE TWO LEVEL SIMPLIFY® CERVICAL ARTIFICIAL DISC

• Prosidyan - A Post-Market, Prospective, Multi-Center, Nonrandomized Study to Assess Posterlateral Lumbar Fusions Using FIBERGRAFT® BG MATRIX.

• 4WEB - Prospective Single Center study of 4WEB® Medical Lateral Spine Truss System Compared to Retrospective Analysis of PEEK Implants: Clinical and Radiographic Outcomes.

• Centinel - A Multicenter, Prospective, Randomized Controlled Trial Comparing the Safety and Effectiveness of prodisc® C SK and prodisc® C Vivo to Mobi-C® Cervical Disc in the Treatment of Two-Level Symptomatic Cervical Disc Disease (SCDD)

• Cerapedics – A multicenter, prospective, randomized IDE study evaluating the safety and effectiveness of P-15L bone graft in TLIF in subjects with degenerative disc disease

• Providence- Safety and Effectiveness of Posterior Cervical Stabilization System (PCSS) as an adjunct to posterior cervical fusion, when used in combination with ACDF in the treatment of multi-level cervical degenerative disease.

• Spineart- A Multicenter, Prospective, Randomized, Clinical trial comparing the safety and effectiveness of the Baguera C Cervical Disc prothesis to the Mobi-C Cervical disc for the treatment of patients with symptomatic cervical disc disease at a single level.

• Spineart- A Multicenter, Prospective, Randomized, Clinical trial comparing the safety and effectiveness of the Baguera C Cervical Disc prothesis to the Mobi-C Cervical disc for the treatment of patients with symptomatic cervical disc disease at two contiguous levels.

• Kuros Magnetos- A Prospective, randomized, single-center study to Assess the performance of MagnetOs Putty compared to a cell-based allograft in patients undergoing up to three-level instrumented posterolateral lumbar Fusion (PLF)

• restor3d- Clinical and Radiographic Assessment of a 3D Printed Titanium Porous Interbody Fusion Device in the Cervical Spine used in the Treatment of Degenerative Cervical Disc Disease

• Bioventus- A Prospective, Randomized, Intra-Patient Controlled, Multi-Center Clinical Investigation evaluating OSTEOAMP SELECT® Fiber versus InfuseTM Bone Graft as an autograft substitute in lumbar fusion procedures

• OssDsign- Prospective Observational Spine Fusion Registry For OssDsign® Bone Graft Substitute In Real World Clinical Practice.

• 3Spine- A Prospective Data Collection Study Of Patients Treated with A Single-Level Transforaminal Lumbar Interbody Fusion (TLIF) Stabilized With Pedicle Screws

• 3Spine- An Interventional, Multi-Center Investigation Of The BALANCEDBACK Total Joint Replacement

• NuVasive- A Prospective Multicenter Study Evaluating the Effect of Implant Material and/or Surface Structure on Progression of Fusion in XLIF® Surgery (Ongoing Study)

• Intrinsic- Post-Marketing Clinical Follow-up of an Annular Closure System (Barricaid) (Ongoing Study)

• Aurora- A Prospective, Multi-center Investigation of the DEXA-C Anterior Cervical Interbody System (Ongoing Study)

CLOSED

• Numerous comparison studies involving Aspen interspinous process fixation versus pedicle screw fixation in ALIF and LLIF lumbar fusion

• Comparison of Max Access Transforaminal Lumbar Interbody Fusion to XLIF/Posterior Spinal fusion for spondylolisthesis. Multicenter Study

• Cellentra Viable Cell Bone Matrix (VCBM) in 2 and 3 level Anterior Cervical Discectomy and Fusion Outcomes Study

• Cellentra Viable Cell Bone Matrix Posterolateral Lumbar Fusion

• A Prospective, Multicenter Study Investigating Re-herniation Risk Factors and Associated Costs in Primary Lumbar Disc Herniation Patients

• A Prospective, Randomized Study of Instrumented, Posterolateral Spinal Fusions with OsteoAMP

• IDE Clinical Prospective Study with one level Simplify cervical artificial disc replacement

• IDE Clinical Prospective Study with two level Simplify cervical artificial disc replacement

• Spineology - The Rampart™ Duo Clinical (RaDical) Study

• FzioMed Oxiplex Confirmatory IDE Study in lumbar discectomy patients

• RTI - Clinical Evaluation of Fortilink® TETRAfuse® Interbody Fusion Device in Subjects with Degenerative Disc Disease (FORTE)

• Bio2 - Safety and Effectiveness of Bio2 Vitrium® Cervical Cage in Anterior Cervical Discectomy and Fusion. A Randomized, Controlled Non-inferiority, Pivotal Stud.

• Burst Biologics - Multicenter Prospective Registry to Evaluate Use and Outcomes of Burst Biologics Products in Spinal Fusion Surgery

• Pacira - A multicenter, prospective, active controlled, real world, Phase 4 study of EXPAREL in multimodal regimens compared with standard of care for postsurgical pain management in subjects undergoing lumbar posterior spine surgeries

• Intrinisic – A Multicenter, prospective Evaluation of Lumbar Discectomy with Additional Implantation of an Annular Closure Device in Patients with Large Postsurgical Annular Defects for Prevention of Lumbar Disc Re-herniation

• Strenge KB, Mangan DB, Idusuyi OB: Postoperative toxic shock syndrome after excision of a ganglion cyst from the ankle. J Foot Ankle Surg 45:275-7, 2006.

• Strenge KB, Idusuyi OB: Technique tip: percutaneous screw fixation of posterior malleolar fractures. Foot Ankle Int 27:650-2, 2006.

• Richardson TD, Pineda SJ, Strenge KB, Van Fleet TA, MacGregor M, Milbrandt JC, Espinosa JA, Freitag P: Serum titanium levels after instrumented spinal arthrodesis. Spine 33:792-6, 2008.

• Bae HW, Strenge KB, Ashraf N, Badura JM, Peckham SM, McKay WF: Transient soft-tissue edema associated with implantation of increasing doses of rhBMP-2 on an absorbable collagen sponge in an ectopic rat model. J Bone Joint Surg Am. 2012 Oct 17;94(20):1845-52.

• Panchal R, DenHaese R, Hill CP, Strenge KB, et al: Anterior and Lateral Lumbar Interbody Fusion with Supplemental Interspinous Process Fixation: Outcomes from a Multicenter, Prospective, Randomized, Controlled Study. International Journal of Spine Surgery 12:1-13, 2018.

• Hill CP, Strenge KB (2019) Early Clinical Outcomes Comparing Porous PEEK, Smooth PEEK, and Structural Allograft Interbody Devices for Anterior Cervical Discectomy and Fusion. J Spine Neurosurg 8:1.

• Nunley P, Strenge K, Huntsman K, et al. (December 08, 2021) Lumbar Discectomy with Barricaid Device Implantation in Patients at High Risk of Reherniation: Initial Results from a Postmarket Study. Cureus 13(12): e20274. doi:10.7759/cureus.20274

• Daffner S D, Bunch J T, Burton D C, et al. (March 09, 2022) Better Functional Recovery After Single-Level Compared with Two-LevelPosterolateral Lumbar Fusion. Cureus 14(3): e23010. DOI 10.7759/cureus.23010

• Coric D, Guyer R, Bae H, Nunley P, Strenge KB, et al: Imaging outcome at 24-month follow-up in a prospective, multicenter study of two-level cervical arthroplasty with a PEEK on ceramic artificial disc. The Spine Journal. Sept 2022; 22:9S; 29

• Coric D, Guyer R, Bae H, Nunley P, Strenge KB, et al: Clinical outcome of a prospective, controlled, multicenter study evaluating two-level cervical arthroplasty with a PEEK-on-ceramic artificial disc. The Spine Journal. Sept 2022; 22:9S; 11.

• Strenge, K. B., C. P. DiPaola, L. E. Miller, C. P. Hill and R. G. Whitmore (2019). Multicenter study of lumbar discectomy with Barricaid annular closure device for prevention of lumbar disc reherniation in US patients: A historically controlled post-market study protocol. Medicine (Baltimore) 98(35): e16953.

• Nunley P, Strenge KB, Huntsman K, Bae H, et al. (2023) Lumbar Discectomy With Bone Anchored Annular Closure Device in Patients with Large Annular Defects: One Year Results. Cureus: DOI: 10.7759/cureus.

• Strenge KB, Idusuyi OB: “Percutaneous screw fixation of posterior malleolus fractures.” Mid-America Orthopaedic Association 23rd Annual Meeting, Amelia Island, FL, April 2005.

• Richardson TD, Pineda SJ, Strenge KB, Van Fleet TA, MacGregor M, Milbrandt JC, Espinosa JA, Freitag P: “Serum titanium levels after instrumented spinal arthrodesis.” Mid-America Orthopaedic Association 24th Annual Meeting, Boca Raton, FL, April 2007.

• Richardson TD, Pineda SJ, Strenge KB, Van Fleet TA, MacGregor M, Milbrandt JC, Espinosa JA, Freitag P: “Elevated serum titanium levels in patients with titanium spinal instrumentation.” 17th Annual SIU Trainee Research Symposium, Springfield, IL, April 2007.

• Richardson TD, Pineda SJ, Strenge KB, Van Fleet TA, MacGregor M, Milbrandt JC, Espinosa JA, Freitag P: “Serum titanium levels after instrumented spinal arthrodesis.” SIU Resident Research Day, Springfield, IL, May 2007.

• Richardson TD, Pineda SJ, Strenge KB, Van Fleet TA, MacGregor M, Milbrandt JC, Espinosa JA, Freitag P: “Serum titanium levels after instrumented spinal arthrodesis.” North American Spine Society 22nd Annual Meeting, Austin, TX, October 2007.

• Richardson TD, Pineda SJ, Strenge KB, Van Fleet TA, MacGregor M, Milbrandt JC, Espinosa JA, Freitag P: “Serum titanium levels after instrumented spinal arthrodesis.” 2nd Combined Meeting of the American Orthopaedic Association and the Canadian Orthopaedic Association, Québec City, Québec, June 2008.

• Kim K, DenHaese R, Hill C, Strenge B: “The Aspen MIS Fusion System versus Pedicle Screw Fixation, A Comparison of Supplemental Posterior Fixation in ALIF and LLIF: Intraoperative Outcomes in a Prospective Randomized Multicenter Trial.” Society for Minimally Invasive Spine Surgery Global Forum 2014, Miami, FL, September 2014.

• DenHaese R, Hill C, Strenge B, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Lateral Lumbar Interbody Fusion with Modular Plate Fixation: Initial Experience with a Novel Technology. Intra‐Op and 1‐Year Outcomes.” American Academy of Neurological Surgeons 84th Annual Meeting, Chicago, IL, May 2015.

• Strenge KB: “Supplemental MIS Fixation Options for LLIF” Solutions Showcase, North American Spine Society Annual Meeting, Chicago, IL, October 2015.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Passias P, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Interspinous process fixation versus pedicle screw fixation: outcomes in a prospective randomized multi-center trial.” European Academy of Neurosurgeons Annual Meeting, October 2015.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Passias P, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Lateral versus Anterior Lumbar Interbody Fusion: Outcomes from a Prospective Multi-center Study.” European Academy of Neurosurgeons Annual Meeting, October 2015.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Passias P, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Interspinous Process Fixation versus Pedicle Screw Fixation in Circumferential Fusion: 1‐Year Outcomes from a Prospective Randomized Multi‐Center Trial.” Society for Minimally Invasive Spine Surgery Global Forum, Las Vegas, NV, November 2015.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Passias P, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Anterior versus Lateral Circumferential Lumbar Fusion: Outcomes from a Prospective Multi‐center Study.” Society for Minimally Invasive Spine Surgery Global Forum, Las Vegas, NV, November 2015.

• DenHaese R, Hill C, Strenge B, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Lateral Lumbar Interbody Fusion with Modular Plate Fixation: Initial Experience with a Novel Technology. Intra‐Op and 1‐Year Outcomes.” Society for Minimally Invasive Spine Surgery Global Forum, Las Vegas, NV, November 2015.

• Strenge KB: “Principles of Lateral Lumbar Interbody Fusion and Posterior MIS Fixation Solutions.” Zimmer Biomet National Sales Meeting, Denver, CO, February 2016.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Passias P, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Interspinous Process Fixation versus Pedicle Screw Fixation in Circumferential Fusion: 1‐Year Outcomes from a Prospective Randomized Multi‐Center Trial.” 32nd Annual Meeting of the Section on Disorders of the Spine and Peripheral Nerves, March 2016.

• DenHaese R, Hill C, Strenge B, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Lateral Lumbar Interbody Fusion with Modular Plate Fixation: Initial Experience with a Novel Technology. Intra‐Op and 1‐Year Outcomes.” 32nd Annual Meeting of the Section on Disorders of the Spine and Peripheral Nerves, March 2016.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Passias P, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Interspinous Process Fixation versus Pedicle Screw Fixation in Circumferential Fusion: 1‐Year Outcomes from a Prospective Randomized Multi‐Center Trial.” International Society for the Advancement of Spine Surgery Annual Meeting, Las Vegas, NV, April 2016.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Passias P, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Anterior versus Lateral Circumferential Lumbar Fusion: Outcomes from a Prospective Multi‐center Study.” International Society for the Advancement of Spine Surgery Annual Meeting, Las Vegas, NV, April 2016.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Passias P, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Interspinous process fixation versus pedicle screw fixation in circumferential arthrodesis: 1-year outcomes from a prospective randomized multi-center trial.” BritSpine 2016, Nottingham, United Kingdom, April 2016.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Passias P, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Interspinous Process Fixation versus Pedicle Screw Fixation in Circumferential Fusion: 1‐Year Outcomes from a Prospective Randomized Multi‐Center Trial.” SpineWeek 2016, Singapore, Malaysia, May 2016.

• Kim K, DenHaese R, Hill C, Strenge B, de Moura A, Passias P, Kranenburg A, Dennis M, Cappuccino A, Thaiyananthan T, Arnold P, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Anterior versus Lateral Circumferential Lumbar Fusion: Outcomes from a Prospective Multi‐center Study.” SpineWeek 2016, Singapore, Malaysia, May 2016.

• DenHaese R, Hill C, Strenge B, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Lateral Lumbar Interbody Fusion with Modular Plate Fixation: Initial Experience with a Novel Technology.” Intra‐Op and 1‐Year Outcomes. SpineWeek 2016, Singapore, Malaysia, May 2016.

• DenHaese R, Hill C, Strenge B, Ferry C, Martin K, Moore C, Martineck S, Bejin B: “Perioperative Experience with a Lateral Interbody Fusion Cage possessing Integrated Modular Plate Fixation.” SpineWeek 2016, Singapore, Malaysia, May 2016.

• Strenge KB: “nanOss Advanced Bone Graft Substitute: The Clinical Perspective.” RTI Surgical Spring Spine Symposium, New Orleans, LA, May 2018

• Strenge KB, Hill CP: “Early 3-Month Cervical Outcomes of the Fortilink TETRAfuse Interbody Fusion Device in Subjects with Degenerative Disc Disease Study – The FORTE Study” AANS 2020 Eposter

• Strenge, KB: “Effectiveness of a Bone-Anchored Implant to Prevent Recurrent Lumbar Disc Herniation: 5-Year Multicenter RCT Results” Spine Summit, Las Vegas, Nevada, February 2022

• Novel 3D Printed PEKK Cervical Interbody Device: Positive Results from a Non-Randomized, Prospective Study. CSRS

• Forty-eight-month clinical outcomes of a prospective, controlled, multicenter study evaluating two-level cervical disc arthroplasty with a PEEK-on-ceramic artificial disc. CSRS

Strenge KB, Fisk JR: “Spinal Orthoses for Pain.” Atlas of Orthoses and Assistive Devices, 4th Edition, edited by Hsu JD, Michael JW, and Fisk JR. Elsevier, Philadelphia, 2008.

• Vertera porous PEEK lateral spacer

• Zimmer Biomet expandable lateral spacer

• Zimmer Biomet expandable TLIF spacer

• CoreLink lateral retractor

• CoreLink lateral spacer and plate

• Stryker K2M lateral retractor

• ATEC MIS pedicle screw system

• ATEC titanium lateral spacer and plate

• Zimmer Biomet titanium TLIF/PLIF spacer

• Expanding Innovations expandable lateral spacers

• Spineology Duo Wide PEEK lateral spacer

• Atlas cervical plate and expandable spacers

• Atlas expandable ALIF spacer

• restor3d ALIF spacer

• Vertera porous PEEK TLIF/PLIF spacer